Motif ID: MEF2{A,B,C,D}.p2

Z-value: 1.129


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
MEF2A 4205 myocyte enhancer factor 2A
MEF2B 100271849 myocyte enhancer factor 2B
MEF2BNB-MEF2B 4207 MEF2BNB-MEF2B readthrough
MEF2C 4208 myocyte enhancer factor 2C
MEF2D 4209 myocyte enhancer factor 2D

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
MEF2Cchr5_-_88199868-0.572.6e-03Click!
MEF2Dchr1_-_156470565-0.433.0e-02Click!
MEF2BNB-MEF2Bchr19_-_19303222-0.252.3e-01Click!
MEF2Achr15_+_1001062140.252.3e-01Click!
MEF2Bchr19_-_19281090,
chr19_-_19281062		0.193.6e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_76944585 5.337 NM_001565
 CXCL10
chemokine (C-X-C motif) ligand 10
chr7_-_41742666 3.206 NM_002192
 INHBA
inhibin, beta A
chr10_+_91152321 3.054 NM_001548
 IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr17_-_34207308 2.637 NM_002985
 CCL5
chemokine (C-C motif) ligand 5
chr4_-_76957139 2.013 NM_005409
 CXCL11
chemokine (C-X-C motif) ligand 11
chr10_+_91092238 1.933 NM_001031683
 IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr10_+_69869249 1.803 NM_032578
 MYPN
myopalladin
chr11_+_5710926 1.520 TRIM22
tripartite motif containing 22
chr6_+_127898318 1.441 NM_001010905
 C6orf58
chromosome 6 open reading frame 58
chr10_+_111765725 1.419 NM_019903
 ADD3
adducin 3 (gamma)
chr8_+_120079423 1.309 NM_006438
 COLEC10
collectin sub-family member 10 (C-type lectin)
chr2_+_168043792 1.270 NM_001199144
NM_001199145
 XIRP2

xin actin-binding repeat containing 2

chr10_-_75401199 1.242 MYOZ1
myozenin 1
chr4_+_89299874 1.242 NM_001165136
NM_017912
 HERC6

hect domain and RLD 6

chr1_+_15990300 1.238


chr1_+_28585959 1.228 NM_031459
 SESN2
sestrin 2
chr21_+_27011588 1.211 NM_021219
 JAM2
junctional adhesion molecule 2
chr11_+_69467210 1.198 CCND1
cyclin D1
chr17_-_39280377 1.195 NM_031854
 KRTAP4-12
keratin associated protein 4-12
chr17_-_74483806 1.190 NM_001005498
 RHBDF2
rhomboid 5 homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
4.28 2.71e-02 GO:0030049 muscle filament sliding
4.28 2.71e-02 GO:0033275 actin-myosin filament sliding
4.17 3.69e-02 GO:0070252 actin-mediated cell contraction
2.46 4.43e-03 GO:0003012 muscle system process
2.34 4.99e-02 GO:0006936 muscle contraction
2.19 2.83e-03 GO:0006875 cellular metal ion homeostasis
2.18 1.08e-03 GO:0030003 cellular cation homeostasis
2.17 2.89e-03 GO:0055065 metal ion homeostasis
2.12 1.12e-03 GO:0055080 cation homeostasis
1.97 9.04e-04 GO:0006873 cellular ion homeostasis
1.94 1.35e-03 GO:0055082 cellular chemical homeostasis
1.91 1.36e-03 GO:0050801 ion homeostasis
1.75 3.88e-03 GO:0048878 chemical homeostasis
1.71 3.96e-02 GO:0019725 cellular homeostasis
1.19 1.27e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
3.50 4.00e-06 GO:0030017 sarcomere
3.42 5.81e-07 GO:0030016 myofibril
3.27 5.67e-06 GO:0044449 contractile fiber part
3.22 2.60e-06 GO:0043292 contractile fiber
1.64 1.34e-05 GO:0044421 extracellular region part
1.58 3.84e-03 GO:0005615 extracellular space
1.32 1.15e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.67 1.91e-02 GO:0008092 cytoskeletal protein binding